Body CompositionMetabolic FunctionInsulin SensitivityFat OxidationEnergy Regulation10 mg / vial
Purity: 99.88%
Batch: SJZJA-0120
Tested by HPLC-UV-MS
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https://bioflexresearch.co/reta
What it is
Retatrutide (LY3437943) is an investigational triple receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors — producing some of the most significant metabolic changes observed in clinical peptide research to date.
Mechanism of action
GLP-1 reduces appetite and slows gastric emptying. GIP enhances insulin secretion and improves nutrient signaling. Glucagon increases hepatic glucose output and drives fat oxidation and thermogenesis. The triple-agonist combination produces synergistic, additive metabolic impact across all three pathways simultaneously.
Research context
Phase 2 trials published in the New England Journal of Medicine (2023) showed up to 24.2% body weight reduction at 48 weeks at the 12 mg dose — surpassing tirzepatide and semaglutide in comparable timeframes.
Research areas
Body CompositionMetabolic FunctionInsulin SensitivityFat OxidationEnergy Regulation
⚠ For research purposes only. Not approved for human use by the FDA. Not for human consumption.
Research dosing reference
Starting dose
0.5 – 1 mg
Frequency
Once weekly
Max studied
12 mg / wk
Route
Subcutaneous
Protocol notes
Increase by 0.5–1 mg every 4 weeks based on tolerance. Three arms studied in phase 2 trials: 4 mg, 8 mg, and 12 mg weekly.
Commonly observed side effects
Nausea, reduced appetite, mild GI discomfort — consistent with GLP-1 class compounds. Most common during dose escalation.
⚠ Dosing data sourced from published clinical literature. For research reference only.
Reconstitution protocol
01
Draw 1–2 mL of bacteriostatic water into a clean syringe.
02
Insert needle through rubber stopper angled toward the glass wall.
03
Slowly push water down the side of the vial — never directly at the powder.
04
Swirl gently 30–60 seconds until fully dissolved. Solution should be clear.
05
Label with reconstitution date and refrigerate immediately.
Bacteriostatic water volume
1–2 mL bacteriostatic water per 10 mg vial
Dose calculation referenceAt 10 mg in 2 mL: each 0.1 mL = 0.5 mg · each 0.2 mL = 1 mg
⚠ Always use bacteriostatic water for multi-dose vials. Never shake — always swirl gently.
Dose Calculator
Enter how much bacteriostatic water you added to your 10mg vial and your target dose. The calculator shows exactly how many units to draw on a standard U-100 insulin syringe.
10 mg
Draw to this mark on your syringe
— units
— mL
Concentration: — mg/mL
⚠ For research reference only. Calculations assume a standard U-100 insulin syringe (100 units = 1 mL). Always verify your measurements.
Injection protocol
01
Draw calculated dose volume into insulin syringe.
02
Select injection site and clean with alcohol swab. Allow to dry completely.
03
Pinch skin gently, insert needle at 45–90° angle.
04
Slowly depress plunger. Remove needle and apply light pressure.
05
Dispose of syringe safely. Log date, site, and volume.
Recommended needle
29–31 gauge insulin syringe
Injection sites
Abdomen, outer thigh, or deltoid. Rotate sites each week.
⚠ Always rotate injection sites. Never reuse syringes. Dispose of sharps properly.
Storage conditions
Unreconstituted
2–8°C refrigerated · Up to 24 months
Reconstituted
2–8°C refrigerated · Use within 28 days
Stability notes
Avoid freeze-thaw cycles. Keep away from direct light. Do not use if solution appears cloudy or contains visible particulates.
⚠ Keep away from children. Do not use if solution appears cloudy or contains particulates.
Educational Videos
Step-by-step video guides coming soon. Contact us via WhatsApp to be notified when videos go live.