Tesamorelin is a synthetic analog of Growth Hormone-Releasing Hormone (GHRH) — a 44-amino acid peptide that stimulates the pituitary gland to produce and secrete growth hormone in a natural, pulsatile pattern.
Mechanism of action
Binds to GHRH receptors on pituitary somatotroph cells, triggering endogenous GH release. Unlike direct GH administration, Tesamorelin preserves the natural feedback loop, producing physiologically appropriate GH pulses that stimulate IGF-1 production in the liver.
Research context
One of the few GHRH analogs with significant clinical trial data. Studies have demonstrated meaningful reductions in visceral adipose tissue, improvements in body composition, and favorable effects on lipid metabolism.
⚠ For research purposes only. Not approved for human use by the FDA. Not for human consumption.
Research dosing reference
Starting dose
1 mg
Frequency
Once daily
Max studied
2 mg / day
Route
Subcutaneous
Protocol notes
1–2 mg subcutaneously once daily, typically in the evening to align with natural GH release patterns.
Commonly observed side effects
Injection site reactions, fluid retention, joint discomfort, and tingling extremities — consistent with GH-class compounds.
⚠ Dosing data sourced from published clinical literature. For research reference only.
Reconstitution protocol
01
Draw 1–2 mL of bacteriostatic water into a clean syringe.
02
Insert needle through rubber stopper angled toward the glass wall.
03
Slowly push water down the side of the vial.
04
Swirl gently 30–60 seconds until fully dissolved. Solution should be clear.
05
Label with reconstitution date and refrigerate immediately.
Bacteriostatic water volume
1–2 mL bacteriostatic water per 10 mg vial
Dose calculation referenceAt 10 mg in 2 mL: each 0.1 mL = 0.5 mg · each 0.2 mL = 1 mg
⚠ Always use bacteriostatic water for multi-dose vials. Never shake — always swirl gently.
Dose Calculator
Enter how much bacteriostatic water you added to your 10mg vial and your target dose. The calculator shows exactly how many units to draw on a standard U-100 insulin syringe.
10 mg
Draw to this mark on your syringe
— units
— mL
Concentration: — mg/mL
⚠ For research reference only. Calculations assume a standard U-100 insulin syringe (100 units = 1 mL). Always verify your measurements.
Injection protocol
01
Draw calculated dose into insulin syringe.
02
Administer in the evening on an empty stomach for optimal GH pulse alignment.
03
Clean injection site with alcohol swab and allow to dry.
04
Pinch skin, insert at 45–90°, slowly inject.
05
Remove, apply pressure, dispose safely. Log date, dose, and site.
Recommended needle
29–31 gauge insulin syringe
Injection sites
Abdomen preferred. Rotate sites daily.
⚠ Always rotate injection sites. Never reuse syringes. Dispose of sharps properly.
Storage conditions
Unreconstituted
2–8°C refrigerated · Up to 24 months
Reconstituted
2–8°C refrigerated · Use within 21 days
Stability notes
Avoid freeze-thaw cycles. Keep away from direct light. Do not use if solution appears cloudy or contains particles.
⚠ Keep away from children. Do not use if solution appears cloudy or contains particulates.
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